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Moreover, astrocytes in AD often exhibit impaired phagocytic capacity and defective immune clearance, resulting in the accumulation of neuronal debris and secondary iron release, further exacerbating local cytotoxicity and iron dyshomeostasis (Zeng et al., 2025)

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Ethics declarations Ethics approval and consent to participate The animal study was performed according to the institutional animal care and use committee of the First Affiliated Hospital, Zhejiang University School of Medicine and approved (2023 702) by the Tab of Animal Experimental Ethical Inspection of the First Affiliated Hospital, Zhejiang University School of Medicine (date of approval: February 22, 2023)

Detoxification: It supports liver health by aiding in the removal of toxins and heavy metals from the body

NTBI is highly detrimental, as it generates large amounts of ROS that can cause damage to multiple organs, including the liver, stomach, heart, pancreas and brain [3740]

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