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doi: 10.1016/j.biopha.2023.115568 47 RodovalhoVRLuzBSRRabahHdo CarmoFLRFoladorELNicolasAet al

3.1.3 Mechanistic insights Metformin preserves mitochondrial integrity, a key determinant of I/R injury, by stabilizing membrane potential, inhibiting complex I during early reperfusion and preventing mitochondrial permeability transition pore (mPTP) opening, thus limiting ROS generation and apoptosis (Osorio-Llanes et al., 2023

Metabolic Function: It can flag underlying metabolic stress long before other, more common markers start to show issues, giving you time to intervene

In patients with T2DM, this pathway is impaired across various tissues, contributing to insulin resistance and metabolic dysregulation (117)

Store sealed in a cool, dry and dark place

Discontinue use and seek medical advice if symptoms worsen